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Names
X
Name
Species
Main
RECQL2
Homo sapiens
False
WRN
Homo sapiens
True
Keywords
+
Location
+
Subcellular Localisation
X
Stage
Description
Details
Links
Interphase
nucleolus
only in proliferating human cells. Nucleoplasmic in serum starved cell, after ActD, + in the mouse.
PubMed:11420665
PubMed:11971179
PubMed:15635413
PubMed Central:98284027
PubMed Central:11027336
S - meiosis
repair foci
with RP-A in hydroxyurea arrested cells
PubMed:11256630
Interphase
repair foci
with RPA and rad51 after DNA damage. Partial co-localisation with PML bodies
PubMed:11380620
PubMed:12384494
PubMed:17118963
PubMed:16141234
Protein Sequence
X
MwPredict
PIPredict
MwActual
PIActual
AANo
Links
162.5
5.96
1432
Entrez Protein:Q14191
PubMed:0010647186
PubMed:11257107
OMIM:277700
Uniprot:Q14191
157.3
6.1
1401
Entrez Protein:NP_035851
Annotation
X
Start
End
Domain
Description
53
232
35ExoC
545
740
DEAD box
778
859
Helicase
1150
1229
HRDC
1403
1406
NLS
also nucleolar targetting
47
226
35ExoC
85
91
NLS
509
704
DEAD box
743
824
Helicase
1115
1194
HRDC
1336
1339
NLS
Biological Process
X
GO ID
Term
Links
GO:0006281
DNA repair
PubMed:11257107
GO:0006261
DNA-dependent DNA replication
pubmed:18209099
GO:0006312
mitotic recombination
PubMed:11316787
GO:0000723
telomere maintenance
PubMed:15591207
GO:0006360
transcription from Pol I promoter
PubMed:11971179
GO:1902153
regulation of response to DNA damage checkpoint signaling
pubmed:2215942
GO:0070828
heterochromatin organization
pubmed:25931448
Molecular Function
X
GO ID
Term
Links
GO:0008408
3.-5. exonuclease activity
PubMed:11257107
GO:0003684
damaged DNA binding
PubMed:14534320
GO:0003678
DNA helicase activity
PubMed:11257107
GO:0044806
G-quadruplex DNA unwinding
pubmed:30279242
Other Function
X
Function
Links
Expression
X
Experiment
Detail
Links
Related Genes
X
Name
Species
Links
RecQ
Escherichia coli
Sgs1
Saccharomyces cerevisiae
PubMed:11179234
PubMed:11290710
ffa-1
Xenopus laevis
PubMed:11238454
Rqh1
Schizosaccharomyces pombe
History
X
Created On
Last Changed
2001-04-23 13:06:09
2006-07-13 16:14:51